招生工作
导师介绍
晏伟伟
博士 副研究员 硕士生导师
细胞代谢与疾病干预研究组
研究方向：蛋白质翻译后修饰和肿瘤代谢
电子邮件(E-mail)：wwyan@sinh.ac.cn
电话(Tel)：021-
简历

2025-至　 今： 中国科学院上海营养与健康研究所 副研究员
2024-2025：上海交通大学附属上海市第一人民医院-助理研究员
2019-2024：中国科学院生物化学与细胞生物学研究所-博士后
2015-2018：复旦大学-医学系统生物学-博士
2012-2015：上海交通大学-生物化学与分子生物学-硕士
2008-2012：安庆师范大学-生物科学-学士

研究内容

以蛋白质翻译后修饰为核心切入点，深入研究细胞代谢调控的分子机制，旨在为肿瘤及代谢性疾病的临床诊疗筛选可靠生物标志物，并围绕关键靶点开展药物研究工作，为延缓疾病发生发展、改善患者预后提供理论依据和潜在治疗策略。具体研究方向如下：
1. 线粒体生物合成的分子调控机制及其在疾病发生中的作用；
2. 新型蛋白质翻译后修饰（如精氨酸甲基化修饰等）的鉴定、功能及调控网络；
3. 细胞感知营养与代谢物的分子机制，及其在肿瘤中的功能及机制。

代表性论文(* 通讯作者）
  1. Yan, Weiwei*; Liu, Xun; Qiu, Xuefeng; Zhang, Xuebin; Chen, Jiahui; Xiao, Kai; Wu, Ping; Peng, Chao; Hu, Xiaolin; Wang, Zengming; Qin, Jun; Sun, Liming; Chen, Luonan; Wu, Denglong; Huang, Shengsong*; Yin, Lichen*; Li, Zhenfei*; PRMT5-mediated FUBP1 methylation accelerates prostate cancer progression. Journal of Clinical Investigation 2024;134(18):e175023
  2. Yan, Weiwei#; Xie, Chengmei#; Sun, Sijun#; Zheng, Quan#; Wang, Jingyi; Wang, Zihao; Man, Cheukhim; Wang, Haiyan; Yang, Yunfan; Wang, Tianshi; Shi, Leilei; Zhang, Shengjie*; Huang, Chen*; Xu, Shuangnian*; Wang, Yiping*; SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression. The EMBO Journal 2024;43(12):2337-2367
  3. Yan, Weiwei; Liang, Yunliu; Zhang, Qixiang; Wang, Di; Lei, Mingzhu; He, Xianghuo; Lei, Qunying; Wang, Yiping*; Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis. EMBO Reports 2018;19(12):e46377
  4. Zhang, Xuebin#; Wang, Zengming#; Huang, Shengsong#; He, Dongyin#; Yan, Weiwei; Zhuang, Qian; Wang, Zixian; Wang, Chenyang; Tan, Qilong; Liu, Ziqun; Yang, Tao; Liu, Ying; Ren, Ruobing; Li, Jing; Butler, William; Tang, Huiru; Wei, Gonghong; Li, Xin*; Wu, Denglong*; Li, Zhenfei*; Active DHEA uptake in the prostate gland correlates with aggressive prostate cancer. Journal of Clinical Investigation 2023;133(24):e171199
  5. Xia, Di; Xu, Guiping; Zhang, Yingting; Yan, Weiwei; Pan, Xiaorong*; Tong, Jianhua*. Targeting inhibition of TCTP could inhibit proliferation and induce apoptosis in AML cells. Cellular Signalling 2024;117:111074
  6. Zhong, Xingyu; Yuan, Xiuming; Xu, Yingying; Yin, Miao; Yan, Weiwei, Zou, Shaowu; Wei, Liming, Lu, Haojie; Wang, Yiping; Lei, Qunying*. CARM1 Methylates GAPDH to regulate glucose metabolism and is suppressed in liver cancer. Cell Reports 2018;24(12):3207-3223
  7. Xia, Di; Zhang, Yingting; Xu, Guiping; Yan, Weiwei; Pan, Xiaorong; Tong, Jianhua*. Sertraline exerts its antitumor functions through both apoptosis and autophagy pathways in acute myeloid leukemia cells. Leukemia & lymphoma 2017;58(9):2208-2217
  8. Zhuang, Likun; Xu, Guiping; Pan, Xiaorong; Lou, Yejiang; Zou, Qingping; Xia Di; Yan, Weiwei; Zhan, Yingting; Jia, Peimin; Tong, Jianhua*. MicroRNA-181a-mediated downregulation of AC9 protein decreases the intracellular cAMP level and inhibits ATRA-induced APL cell differentiation. Cell Death and Disease 2014;5(e1161):1-9