招生工作
导师介绍
陶用珍
博士 副研究员 硕士生导师
中国科学院营养代谢与食品安全重点实验室，慢病代谢示踪与营养干预研究组
研究方向：肿瘤免疫代谢及其营养干预
电子邮件(E-mail)：yztao01@sinh.ac.cn
简历

2021-至 今：中国科学院上海营养与健康研究所 副研
2017-2020：中国科学院上海营养与健康研究所 助研
2013-2017：中国科学院上海生命科学研究院营养科学研究所 助研
2010-2012：美国加州Sanford-Burnham Medical Research Institute 博后
2008-2010：中国科学院上海生命科学研究院/植物生理生态研究所 博后
2004-2008：西安交通大学 博士
2001-2004：西安交通大学与西安工程大学联合培养 硕士
1997-2001：西安工程大学 学士

研究内容

主要聚焦于肝癌细胞与微环境中免疫细胞的代谢重塑及其互作，探究调控肿瘤细胞生长的分子机制。具体如下：
1. 基于课题组的质谱技术，应用靶向和非靶向代谢组学和脂质组学平台，发展稳定同位素的13C-flux代谢通量技术，示踪活体小鼠或细胞的代谢重塑，揭示其调控疾病进程的作用机制；
2. 结合基因、蛋白和代谢等多组学，应用免疫和分子生物学等技术手段，对动物肿瘤模型和临床样本中肿瘤细胞和微环境互作进行解析，挖掘新的治疗靶点，制定营养干预策略。

代表性论文（#共同第一作者, *共同通讯作者）
  1. Chunzhao Yin, Cunzhen Zhang, Yongqiang Wang, Guijun Liu, Ningning Wang, Ningning Liang, Lili Zhang, Qiaochu Tu, Jingwen Lv, Huimin Jiang, Haoran Ma, Chenxi Du, Min Li, Xuxiao He, Shiting Chen, Jiacheng Guo, Shengxian Li, Jun Qin, Nan Li*, Yongzhen Tao*, Huiyong Yin*. ALDOB/KAT2A interactions epigenetically modulate TGF-β expression and T cell functions in hepatocellular carcinogenesis. Hepatology 2023 Dec 5. doi: 10.1097/HEP.0000000000000704
  2. Guijun Liu, Ningning Wang, Cunzhen Zhang, Min Li, Xuxiao He, Chunzhao Yin, Qiaochu Tu, Xia Shen, Lili Zhang, Jingwen Lv, Yongqiang Wang, Huimin Jiang, Shiting Chen, Nan Li, Yongzhen Tao*, Huiyong Yin*. Fructose-1,6-Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis. Hepatology 2021 Dec;74(6):3037-3055
  3. Yabo Jiang#, Yongzhen Tao#, Xiuping Zhang#, Xubiao Wei, Min Li, Xuxiao He, Bin Zhou, Weixing Guo, Huiyong Yin, Shuqun Cheng. Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma. Mol Oncol 2021 Feb;15(2):710-724
  4. Min Li, Xuxiao He, Weixing Guo, Hongming Yu, Shicheng Zhang, Ningning Wang, Guijun Liu, Rina Sa, Xia Shen, Yabo Jiang, Yufu Tang, Yujuan Zhuo, Chunzhao Yin, Qiaochu Tu, Nan Li, Xiaoqun Nie, Yu Li, Zhimin Hu, Hanwen Zhu, Jianping Ding, Zi Li, Te Liu, Fan Zhang, He Zhou, Shengxian Li, Jiang Yue, Zheng Yan, Shuqun Cheng, Yongzhen Tao*, Huiyong Yin*. Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways. Nat Cancer 2020 Jul;1(7):735-747
  5. Ningning Wang, Hongzhi Liu, Guijun Liu, Min Li, Xuxiao He, Chunzhao Yin, Qiaochu Tu, Xia Shen, Wenqiang Bai, Qiang Wang, Yongzhen Tao*, Huiyong Yin*. Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis. Redox Biol 2020 May;32:101495
  6. Guijun Liu, Aimin Shi, Ningning Wang, Min Li, Xuxiao He, Chunzhao Yin，Qiaochu Tu, Xia Shen, Yongzhen Tao*, Qiang Wang*, Huiyong Yin*. Polyphenolic Proanthocyanidin-B2 suppresses proliferation of liver cancer cells and hepatocellular carcinogenesis through directly binding and inhibiting AKT activity. Redox Biol 2020 Oct;37:101701
  7. Xuxiao He, Min Li, Hongming Yu, Guijun Liu, Ningning Wang, Chunzhao Yin, Qiaochu Tu, Goutham Narla Narla, Yongzhen Tao*, Shuqun Cheng*, Huiyong Yin*. Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing Aldob/Akt/PP2A protein complex. PLoS Biol 2020 Dec 4;18(12):e3000803
  8. Shengxian Li#, Jia Qi#, Yongzhen Tao#, Qinling Zhu, Rong Huang, Yu Liao, Jiang Yue, Wei Liu, Hanting Zhao, HuiyongYin, Yun Sun. Elevated levels of arachidonic acid metabolites in follicular fluid of PCOS patients. Reproduction 2020 Feb;159(2):159-169
  9. Shanshan Zhong, Luxiao Li, Yulei Zhang, Lili Zhang, Jianhong Lu, Shuyuan Guo, Ningning Liang, Jing Ge, Mingjiang Zhu, Yongzhen Tao, Yuncheng Wu, Huiyong Yin. Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. J Clin Invest 2019 Jan 2;129(1):252-267
  10. Hongli Hu, Wenwei Zhu, Jun Qin, Min Chen, Liyan Gong, Long Li, Xiangyuan Liu, Yongzhen Tao, Huiyong Yin, Hu Zhou, Lisha Zhou, Dan Ye, Qinghai Ye, Daming Gao. Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis. Hepatology 2017 Feb;65(2):515-528
  11. Fay J Dufort, Maria R Gumina, Nathan L Ta, Yongzhen Tao, Shannon A Heyse, David A Scott, Adam D Richardson, Thomas N Seyfried, Thomas C Chiles. Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem 2014 Mar 7;289(10):7011-7024
  12. Li Ma, Yongzhen Tao, Angeles Duran, Victoria Llado, Anita Galvez, Jennifer F Barger, Elias A Castilla, Jing Chen, Tomoko Yajima, Aleksey Porollo, Mario Medvedovic, Laurence M Brill, David R Plas, Stefan J Riedl, Michael Leitges, Maria T Diaz-Meco, Adam D Richardson, Jorge Moscat. Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell 2013 Jan 31;152(3):599-611
  13. Yongzhen Tao#, Deng Liu#, et al. Network Identification and Flux Quantification of Glucose Metabolism in Rhodobacter sphaeroides under Photoheterotrophic H2-Producing Conditions. J Bacteriol 2012 Jan;194(2):274-283
  14. Yongzhen Tao, Yanling He, Yongqiang Wu, Fanghua Liu, Zhihua Zhou. Characteristics of a new photosynthetic bacterial strain for hydrogen production and its application in wastewater treatment. Int J Hydrogen Energy 2008 Feb;33(3):963-973
  15. Yongzhen Tao, Yang Chen, Yongqiang Wu, Yanling He, Zhihua Zhou. High hydrogen yield from a two-step process of dark-and photo fermentation of sucrose. Int J Hydrogen Energy 2007 Feb;32(2):200-206