招生工作
导师介绍
彭倩倩
博士 研究员 博士生导师
人类表型组学研究组
研究方向：计算生物学、衰老与复杂疾病分析
电子邮件(E-mail)：pengqianqian@sinh.ac.cn
电话(Tel)：021-54920551
简历

2025.12-至　 今：中国科学院上海营养与健康研究所 研究员
2019.05-2025.11：中国科学院上海营养与健康研究所 副研究员
2015.11-2019.05：中国科学院上海生命科学研究院-马普计算生物学伙伴研究所 副研究员
2013.07-2015.11：中国科学院上海生命科学研究院-马普计算生物学伙伴研究所 助理研究员
2009.09-2013.01：复旦大学 遗传学博士
2006.09-2009.07：山东大学 流行病与卫生统计硕士
2002.09-2006.07：山东大学 统计学学士

研究内容

围绕衰老与复杂疾病，开发衰老量化新方法，依托大型人群队列数据、多组学技术探索衰老与疾病共病潜在的分子基础，建立衰老与疾病的风险预测模型。
1、器官衰老的非线性与异质性量化及共病机制解析
2、跨组学关联图谱及其在衰老与疾病解析中的应用
3、基于多组学的体质特征与代谢性疾病一因多效性解析与预测模型构建

代表性论文（#共同第一作者, *共同通讯作者）
  1. Huang, H.#, Y. Li#, Q. Song#, L. Yuan, Y. Yang, M. Zhu, R. Sun, Y. Hu, C. Xiong, T. Ni, Y. Liu, A. Ruiz-Linares, G. Zhang, F. Liu*, Q. Peng* and S. Wang* (2026) Structural decomposition enables multi-omics dissection of common and organ-specific aging. Sci China Life Sci Doi: 10.1007/s11427-025-3242-5. Online ahead of print
  2. Peng, Q.#,*, Y. K. Cheung, Y. Liu, Y. Wang, J. Tan, Y. Yang, J. Wang, J. J. Han, L. Jin, F. Liu* and S. Wang* (2025) 3D facial imaging: a novel approach for metabolic abnormalities risk profiling. Sci China Life Sci 68(6): 1786-1800
  3. Li, T.#, L. Zuo#, P. Wang, L. Yang, Z. Liu, X. Wang, J. Tan, Y. Yang, J. Wang, Y. Zhou, L. Jin, G. Zhai, J. Chen*, Q. Peng*, G. Zhang* and S. Wang* (2025) TonguExpert: A Deep Learning-Based Algorithm Platform for Fine-Grained Extraction and Classification of Tongue Phenotypes. Phenomics 5(2): 109-122
  4. Li, J., M. Jiang, Q. Wang, Z. Zheng, J. Shen, J. Li, M. Xiong, Y. Zheng, X. Lu, Y. Cai, Y. Fan, L. Geng, Q. Ji, Q. Peng, et al (2025) The X-Age Project to construct a Chinese aging clock. Nat Aging 5(9): 1669-1685
  5. Li, W., Y. Cheng, A. Cui, M. Huang, Q. Huang, Q. Wang, M. Xia, J. Qiu, Q. Peng, J. Li, H. Li, Y. Wang, G. Zong, Y. Zheng, J. Wang, X. Gao, C. Ding, H. Tang, B. H. Jiang, L. Jin, Y. Li and S. Wang (2025) Multiomics Integration of Epigenetics, Proteomics, and Metabolomics Identifies Putative Drug Targets and Improves Early Prediction for Diabetes. Diabetes 74(12): 2418-2431
  6. Lin, C., M. Xia, Y. Dai, Q. Huang, Z. Sun, G. Zhang, R. Luo, Q. Peng, J. Li, X. Wang, H. Lin, X. Gao, H. Tang, X. Shen, S. Wang, L. Jin, X. Hao and Y. Zheng (2025) Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites. Cell Genom 5(4): 100810
  7. Du, S., J. Chen, J. Li, W. Qian, S. Wu, Q. Peng, Y. Liu, T. Pan, Y. Li, S. S. Hadi, J. Tan, Z. Yuan, J. Wang, K. Tang, Z. Wang, Y. Wen, X. Dong, W. Zhou, A. Ruiz-Linares, Y. Shi, L. Jin, F. Liu, M. Zhang and S. Wang (2025) A multi-ancestry GWAS meta-analysis of facial features and its application in predicting archaic human features. J Genet Genomics 52(4): 513-524
  8. Gao, X., J. Li, X. Liu, Q. Peng, H. Jing, S. Hadi, A. E. Teschendorff, S. Wang and F. Liu (2025) FastQTLmapping: an ultra-fast and memory efficient package for mQTL-like analysis. BMC Bioinformatics 26(1): 112
  9. Peng, Q.#, X. Liu#, W. Li#, H. Jing#, J. Li, X. Gao, Q. Luo, C. E. Breeze, S. Pan, Q. Zheng, G. Li, J. Qian, L. Yuan, N. Yuan, C. You, S. Du, Y. Zheng, Z. Yuan, J. Tan, P. Jia, J. Wang, G. Zhang, X. Lu, L. Shi, S. Guo, Y. Liu, T. Ni, B. Wen, C. Zeng, L. Jin, A. E. Teschendorff*, F. Liu* and S. Wang* (2024) Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits. Nat Genet 56(5): 846-860
  10. Qian, Q., Y. Gu, J. Luo, S. Wu, J. Li, J. Li, Q. Peng, W. Chen, Y. Yang, J. Wang, L. Jin, R. Sun, G. Zhang, F. Liu and S. Wang (2025) Genetic and environmental factors affecting hair density in East Asian populations. Br J Dermatol 193(3): 502-513
  11. Qian, Y.#, Q. Peng#, Q. Qian#, X. Gao, X. Liu, Y. Li, X. Fan, Y. Cheng, N. Yuan, S. Hadi, L. Jin, S. Wang* and F. Liu* (2025) A methylation panel of 10 CpGs for accurate age inference via stepwise conditional epigenome-wide association study. Int J Legal Med 139(3): 1193-1203
  12. Yuan, C., X. T. Yu, J. Wang, B. Shu, X. Y. Wang, C. Huang, X. Lv, Q. Q. Peng, W. H. Qi, J. Zhang, et al (2024) Multi-modal molecular determinants of clinically relevant osteoporosis subtypes. Cell Discov 10(1): 28
  13. Peng Q#, Liu Y#, Huels A, Zhang C, Yu Y, Qiu W, Cai X, Zhao Y, Schikowski T, Merches K, Liu Y, Yang Y, Wang J, Zhao Y, Jin L, Zhang L, Krutmann J, Wang S. Genetic Variants in Telomerase Reverse Transcriptase Contribute to Solar Lentigines. J Invest Dermatol 2023 Jun;143(6):1062-1072
  14. Li B#, Kamarck ML#, Peng Q#, Lim FL, Keller A, Smeets MAM, Mainland JD, Wang S (2022) From musk to body odor: Decoding olfaction through genetic variation. PLoS Genet 18(2):e1009564
  15. Zhang M, Wu S, Du S, Qian W, Chen J, Qiao L, Yang Y, Tan J, Yuan Z, Peng Q, Liu Y, Navarro N, Tang K, Ruiz-Linares A, Wang J, Claes P, Jin L, Li J, Wang S (2022) Genetic variants underlying differences in facial morphology in East Asian and European populations. Nat Genet 54(4):403-411
  16. Li J, Glover JD, Zhang H, Peng M, Tan J, Mallick CB, Hou D, Yang Y, Wu S, Liu Y, Peng Q, Zheng SC, Crosse EI, Medvinsky A, Anderson RA, Brown H, Yuan Z, Zhou S, Xu Y, Kemp JP, Ho YYW, Loesch DZ, Wang L, Li Y, Tang S, Wu X, Walters RG, Lin K, Meng R, Lv J, Chernus JM, Neiswanger K, Feingold E, Evans DM, Medland SE, Martin NG, Weinberg SM, Marazita ML, Chen G, Chen Z, Zhou Y, Cheeseman M, Wang L, Jin L, Headon DJ, Wang S (2022) Limb development genes underlie variation in human fingerprint patterns. Cell 185(1):95-112
  17. Huang Y, Li D, Qiao L, Liu Y, Peng Q, Wu S, Zhang M, Yang Y, Tan J, Xu S, Jin L, Wang S, Tang K, Grünewald S (2021) A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese. J Genet Genomics 48(3):198-207
  18. Liu Y, Gao W, Koellmann C, Le Clerc S, Hüls A, Li B, Peng Q, Wu S, Ding A, Yang Y, Jin L, Krutmann J, Schikowski T, Zagury JF, Wang S (2019) Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. J Dermatol Sci 96(1):42-49
  19. Wu S, Zhang M, Yang X, Peng F, Zhang J, Tan J, Yang Y, Wang L, Hu Y, Peng Q, Li J, Liu Y, Guan Y, Chen C, Hamer MA, Nijsten T, Zeng C, Adhikari K, Gallo C, Poletti G, Schuler-Faccini L, Bortolini MC, Canizales-Quinteros S, Rothhammer F, Bedoya G, González-José R, Li H, Krutmann J, Liu F, Kayser M, Ruiz-Linares A, Tang K, Xu S, Zhang L, Jin L, Wang S (2018) Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. PLoS Genet 14(9):e1007640
  20. Peng Q, Li J, Tan J, Yang Y, Zhang M, Wu S, Liu Y, Zhang J, Qin P, Guan Y, Jiao Y, Zhang Z, Sabeti PC, Tang K, Xu S, Jin L, Wang S (2016) EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects. Hum Genet 135(1):99-108
  21. Wu S, Tan J, Yang Y, Peng Q, Zhang M, Li J, Lu D, Liu Y, Lou H, Feng Q, Lu Y, Guan Y, Zhang Z, Jiao Y, Sabeti P, Krutmann J, Tang K, Jin L, Xu S, Wang S (2016) Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Hum Genet 135(11):1279-1286
  22. Tan J#, Peng Q#, Li J, Guan Y, Zhang L, Jiao Y, Yang Y, Wang S, Jin L (2014) Characteristics of dental morphology in the Xinjiang Uyghurs and correlation with the EDARV370A variant. Sci China Life Sci 57(5):510-518
  23. Zhao JY, Qiao B, Duan WY, Gong XH, Peng QQ, Jiang SS, Lu CQ, Chen YJ, Shen HB, Huang GY, Jin L, Wang HY (2014) Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations. Eur Heart J 35(11):733-742
  24. Wang, J., J. Y. Zhao, F. Wang, Q. Q. Peng, J. Hou, S. N. Sun, Y. H. Gui, W. Y. Duan, B. Qiao and H. Y. Wang (2014) A genetic variant in vitamin B12 metabolic genes that reduces the risk of congenital heart disease in Han Chinese populations. PLoS One 9(2): e88332
  25. Zhou, Y., S. N. Wang, H. Li, W. Zha, Q. Peng, S. Li, Y. Chen and L. Jin (2014) Quantitative trait analysis of polymorphisms in two bilirubin metabolism enzymes to physiologic bilirubin levels in Chinese newborns. J Pediatr 165(6): 1154-1160.e1151
  26. Zhou, Y., S. N. Wang, H. Li, W. Zha, X. Wang, Y. Liu, J. Sun, Q. Peng, S. Li, Y. Chen and L. Jin (2014) Association of UGT1A1 variants and hyperbilirubinemia in breast-fed full-term Chinese infants. PLoS One 9(8): e104251
  27. Peng, Q. Q.#, Z. Basang#, C. Y. Cui, L. Li, J. Qian, Q. Gesang, L. Yang, Z. La, Y. De, P. Dawa, N. Qu, Q. Suo, Z. Dan, D. Xiao, X. F. Wang and L. Jin (2013) Physiological responses and evaluation of effects of BMI, smoking and drinking in high altitude acclimatization: a cohort study in Chinese Han young males. PLoS One 8(11): e79346
  28. Lin Q#, Peng Q#, Yao F, Pan XF, Xiong LW, Wang Y, Geng JF, Feng JX, Han BH, Bao GL, Yang Y, Wang X, Jin L, Guo W, Wang JC (2012) A classification method based on principal components of SELDI spectra to diagnose of lung adenocarcinoma. PLoS One 7(3):e34457
  29. Peng Q#, Zhao J, Xue F (2010) A gene-based method for detecting gene-gene co-association in a case-control association study. Eur J Hum Genet 18(5):582-7
  30. Peng Q#, Zhao J, Xue F (2010) PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs. BMC Genet 26;11:6