招生工作
导师介绍
李俞莹
博士 副研究员 硕士生导师
甲状腺激素与代谢调控研究组
研究方向：代谢组织的稳态维持和重塑研究
电子邮件(E-mail)：liyuying@sinh.ac.cn
电话(Tel)：021-54922960
简历

2020.08-至　　今：中国科学院上海营养与健康研究所 副研究员
2019.07-2020.06：香港中文大学 博士后
2018.08-2019.07：香港中文大学 研究助理
2014.08-2018.08：香港中文大学 博士
2010.09-2013.09：中科院上海生命科学研究院 硕士
2006.09-2010.06：武汉大学 生命科学学院 学士

研究内容

围绕代谢性组织脂肪和肌肉稳态维持和重塑的调控机制研究，利用骨骼肌干细胞以及脂肪前体细胞体内外研究系统，结合小鼠模型，借助生物信息分析以及基因编辑等技术，深入解析相关分子在衰老，代谢相关疾病发生发展过程中的作用机制。

代表性论文(* 通讯作者）
  1. Yu J, Shen S, Yan Y, Liu L, Luo R, Liu S, Wu Y, Li Y*, Jiang J*, Ying H*. Iodide Excess Inhibits Thyroid Hormone Synthesis Pathway Involving XBP1-Mediated Regulation. Nutrients 2023 Feb 9;15(4):887.
  2. Ma Y#, Shen S#, Yan Y, Zhang S, Liu S, Tang Z, Yu J, Ma M, Niu Z, Li Z, Wu Y, Zhao L, Lu Z, Wei C, Zhang WJ, Xue Y, Zhai Q, Li Y, Hu C, Jiang J*, Li Y*, Ying H*. Adipocyte thyroid hormone β receptor-mediated hormone action fine-tunes the intracellular glucose and lipid metabolism and systemic homeostasis. Diabetes 2023 May 1;72(5):562-574.
  3. Wang H, Ma M, Li Y, Liu J, Sun C, Liu S, Ma Y, Yan Y, Tang Z, Shen S, Yu J, Wu Y, Jiang J, Wang L, Jin ZB, Ying H*, Li Y*. miR-183 and miR-96 orchestrate both glucose and fat utilization in skeletal muscle. EMBO Rep 2021 Sep 6;22(9):e52247.
  4. Li Y, Yuan J, Chen F, Zhang S, Zhao Y, Chen X, Lu L, Zhou L, Chu CY, Sun H*, Wang H*. Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly. Nat Commun 2020 Jun1;11(1):2725.
  5. Zhou J#, So KK#, Li Y#, Li Y, Yuan J, Ding Y, Chen F, Huang Y, Liu J, Lee W, Li G, Ju Z, Sun H*, Wang H*. Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells. Aging Cell 2019 Oct;18(5):e12996.
  6. Zhao Y#, Zhou J#, He L, Li Y, Yuan J, Sun K, Chen X, Bao X, Esteban MA, Sun H*, Wang H*. MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation. Nat Commun 2019 Dec 19;10(1):5787.
  7. Chen F, Zhou J, Li Y, Zhao Y, Yuan J, Cao Y, Wang L, Zhang Z, Zhang B, Wang CC, Cheung TH, Wu Z, Wong CC, Sun H*, Wang H*. YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells. EMBO J 2019 May 15;38(10):e99727.
  8. Li Y, Chen X, Sun H, Wang H*. Long non-coding RNAs in the regulation of skeletal myogenesis and muscle diseases. Cancer Lett 2018 Mar 28;417:58-64.
  9. Chen X, He L, Zhao Y, Li Y, Zhang S, Sun K, So K, Chen F, Zhou L, Lu L, Wang L, Zhu X, Bao X, Esteban MA, Nakagawa S, Prasanth KV, Wu Z, Sun H*, Wang H*. regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity. Cell Discov 2017 Mar 14;3:17002.
  10. Li X#, Li Y#, Zhao L, Zhang D, Yao X, Zhang H, Wang YC, Wang XY, Xia H, Yan J, Ying H*. Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients. Mol Ther Nucleic Acids 2014 Jul 22;3:e177.
  11. Wang YC#, Li Y#*, Wang XY, Zhang D, Zhang H, Wu Q, He YQ, Wang JY, Zhang L, Xia H, Yan J, Li X, Ying H*. Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity. Diabetologia 2013 Oct;56(10):2275-2285.