招生工作
导师介绍
李晶晶
博士 研究员 博士生导师
部门：肿瘤分子生物学课题组
研究方向：肿瘤发生发展和转移，以及药物敏感性的分子机制研究
邮件：jjli@sinh.ac.cn
电话：021-54920655
简历

2023-至今年：中国科学院上海营养与健康研究所，研究员
2020-2022年：中国科学院上海营养与健康研究所，副研究员
2013-2020年：中国科学院营养科学研究所，副研究员
2010-2012年：中国科学院营养科学研究所，博士后
2003-2009年：中国科学院营养科学研究所，博士
1999-2003年：华东师范大学，生物科学，学士

研究内容

1. 利用细胞及动物模型并结合临床样本，研究染色质重塑分子在肿瘤发生、发展、转移和药物敏感性等方面的作用和机制。
2. 关注影响肿瘤命运抉择的内（遗传及表观遗传）外（营养物质感应、免疫微环境及胞外基质重塑）因素，研究其双向互动机制，并在此基础上寻找肿瘤治疗的方案。
3. 利用多种体内外肿瘤模型（主要包括消化系统肿瘤和肺癌），研究肿瘤临床治疗问题，包括肿瘤耐药，治疗策略选择和治疗手段干预等。

代表性论文(* 通讯作者）
  1. Wang YK#, Ma N#, Xu S#, Huang JY, Ni QZ, Cao HJ, Zheng QW, Zhu B, Xia J, Zhang FK, Ding XF, Qiu XS, Chen TW, Wang K, Chen W, Li ZG, Cheng SQ, Xie D*, Li JJ*. PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1. Cell Rep 2023 Apr 25;42(4):112340.
  2. Cao HJ, Jiang H, Ding K, Qiu XS, Ma N, Zhang FK, Wang YK, Zheng QW, Xia J, Ni QZ, Xu S, Zhu B, Ding XF, Chen TW, Qiu L, Chen W, Li ZG, Zhou B, Feng WM, Xie D*, Li JJ*. ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2. Cell Death Differ 2023 Feb;30(2):383-396.
  3. Ni QZ#, Zhu B#, Ji Y, Zheng QW, Liang X, Ma N, Jiang H, Zhang FK, Shang YR, Wang YK, Xu S, Zhang EB, Yuan YM, Chen TW, Yin FF, Cao HJ, Huang JY, Xia J, Ding XF, Qiu XS, Ding K, Song C, Zhou WT, Wu M, Wang K, Lui R, Lin Q, Chen W, Li ZG, Cheng SQ, Wang XF, Xie D*, Li JJ*. PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1. Adv Sci (Weinh) 2023 Jan;10(2):e2202448.
  4. Zheng QW, Ni QZ, Zhu B, Liang X, Ma N, Wang YK, Xu S, Cao HJ, Xia J, Zhang FK, Zhang EB, Qiu XS, Ding XF, Qiu L, Zhang XL, Dong ZH, Li ZG, Zhang XL*, Xie D*, Li JJ*. PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3. Oncogene 2022 Sep;41(36):4244-4256.
  5. Zhang FK#, Ni QZ#, Wang K, Cao HJ, Guan DX, Zhang EB, Ma N, Wang YK, Zheng QW, Xu S, Zhu B, Chen TW, Xia J, Qiu XS, Ding XF, Jiang H, Qiu L, Wang X, Chen W, Cheng SQ, Xie D*, Li JJ*. Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma. Cell Mol Gastroenterol Hepatol 2022;14(1):101-127.
  6. Zheng QW, Ding XF, Cao HJ, Ni QZ, Zhu B, Ma N, Zhang FK, Wang YK, Xu S, Chen TW, Xia J, Qiu XS, Yu DZ, Xie D*, Li JJ*. Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis. Toxins (Basel) 2021 Nov 13;13(11):802.
  7. Ding X#, Chen T#, Shi Q, Nan P, Wang X*, Xie D*, Li JJ*. INTS6 promotes colorectal cancer progression by activating of AKT and ERK signaling. Exp Cell Res 2021 Oct 15;407(2):112826.
  8. Zhang EB#, Zhang X#, Wang K, Zhang F, Chen TW, Ma N, Ni QZ, Wang YK, Zheng QW, Cao HJ, Xia J, Zhu B, Xu S, Ding X, Wang X, Li Z, Cheng S*, Xie D*, Li JJ*. Antifungal agent Terbinafine restrains tumor growth in preclinical models of hepatocellular carcinoma via AMPK-mTOR axis. Oncogene 2021 Aug;40(34):5302-5313.
  9. Ma N#, Wang YK#, Xu S, Ni QZ, Zheng QW, Zhu B, Cao HJ, Jiang H, Zhang FK, Yuan YM, Zhang EB, Chen TW, Xia J, Ding XF, Chen ZH, Zhang XP, Wang K, Cheng SQ, Qiu L, Li ZG, Yu YC, Wang XF, Zhou B, Li JJ*, Xie D*. PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling. Nat Commun 2021 May 24;12(1):3059.
  10. Jiang H, Cao HJ, Ma N, Bao WD, Wang JJ, Chen TW, Zhang EB, Yuan YM, Ni QZ, Zhang FK, Ding XF, Zheng QW, Wang YK, Zhu M, Wang X, Feng J, Zhang XL, Cheng SQ, Ma DJ, Qiu L, Li JJ*, Xie D*. Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis. Proc Natl Acad Sci U S A 2020 Mar 3;117(9):4770-4780.
  11. Yuan YM, Ma N, Zhang EB, Chen TW, Jiang H, Yin FF, Wang JJ, Zhang FK, Ni QZ, Wang X, Bao Y, Wang K, Cheng SQ, Zhang XL, Wang XF, Li JJ*, Xie D*. BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis. Oncogene 2019 Nov;38(48):7281-7293.
  12. Chen TW, Yin FF, Yuan YM, Guan DX, Zhang E, Zhang FK, Jiang H, Ma N, Wang JJ, Ni QZ, Qiu L, Feng J, Zhang XL, Bao Y, Wang K, Cheng SQ, Wang XF, Wang X*, Li JJ*, Xie D*. CHML promotes liver cancer metastasis by facilitating Rab14 recycle. Nat Commun 2019 Jun 7;10(1):2510.
  13. Gao H#, Yin FF#, Guan DX, Feng YX, Zheng QW, Wang X, Zhu M, Zhang XL, Cheng SQ, Chen TW, Jiang H, Zhang EB, Wang JJ, Ni QZ, Yuan YM, Zhang FK, Ma N, Cao HJ, Wang YK, Li JJ*, Xie D*. Liver cancer: WISP3 suppresses hepatocellular carcinoma progression by negative regulation of β-catenin/TCF/LEF signalling. Cell Prolif 2019 May;52(3):e12583.
  14. Li JJ#, Yin HK#, Guan DX, Zhao JS, Feng YX, Deng YZ, Wang X, Li N, Wang XF, Cheng SQ, Bao Y*, Xie D*. Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis. Br J Cancer 2018 May;118(10):1337-1348.
  15. Li JJ, Sun ZJ, Yuan YM, Yin FF, Bian YG, Long LY, Zhang XL*, Xie D*. EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer. J Biol Chem 2017 Jan 20;292(3):1112-1121.
  16. Guan DX, Shi J, Zhang Y, Zhao JS, Long LY, Chen TW, Zhang EB, Feng YY, Bao WD, Deng YZ, Qiu L, Zhang XL, Koeffler HP, Cheng SQ*, Li JJ*, Xie D*. Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade. Hepatology 2015 Dec;62(6):1791-1803.
  17. Li JJ, Xie D. RACK1, a versatile hub in cancer. Oncogene 2015 Apr 9;34(15):1890-1898.
  18. Li JJ, Xie D. The roles and therapeutic potentials of Ephs and ephrins in lung cancer. Exp Cell Res 2013 Jan 15;319(2):152-159.
  19. Li JJ, Liu DP, Liu GT, Xie D*. EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor. Oncogene 2009 Apr 16;28(15):1759-1768.
  20. Li JJ, Qi RZ, Ng GK, Xie D*. Proteomics in gastric cancer research: Benefits and challenges. Proteomics Clin Appl 2009 Feb;3(2):185-196.
  21. Li JJ, Huang CJ, Xie D*. Anti-obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid. Mol Nutr Food Res 2008 Jun;52(6):631-645.
  22. Li JJ, Xie D*. Cleavage of focal adhesion kinase (FAK) is essential in adipocyte differentiation. Biochem Biophys Res Commun 2007 Jun 8;357(3):648-654.