招生工作
导师介绍
何伟杰
博士 副研究员 硕士生导师
食品安全与真菌毒素研究组
研究方向：真菌毒素生物降解
电子邮件(E-mail)：wjhe@sinh.ac.cn
电话(Tel)：021-54920926
简历

2026.03-至　 今： 中国科学院上海营养与健康研究所 副研究员
2021.08-2025.08：华中农业大学 博士后
2020.4-2021.07：湖北省农业科学院粮食作物研究所 助理研究员
2018.01-2020.09：湖北省农业科学院/华中农业大学 博士后
2012.09-2017.12：华中农业大学 生物化学与分子生物学 博士
2009.09-2012.07：华中农业大学 植物学 硕士
2005.09-2009.07：西北师范大学 生物技术 学士

研究内容

围绕食品及其原料中污染的真菌毒素，开发绿色高效的生物降解新方法。通过从自然环境中分离功能性微生物，结合多组学技术、蛋白质化学及计算机模拟，解析微生物降解真菌毒素的分子基础与作用机理，构建基于新型毒素降解酶基因的污染防控新策略。
1、功能性微生物资源筛选及新型毒素降解酶发掘
2、微生物降解真菌毒素的分子基础及降解酶与毒素互作机制解析
3、基于毒素降解酶基因的作物抗毒素生物育种策略构建

代表性论文(* 通讯作者）
  1. He Wei-Jie, Xiong Ren-Yi, Zheng Meng-Ru, Zhang Tian-Tian, Zhang Yu-Shan, Wang Qiang, Zhao Chang-Xing, Huang Tao, Liu Yi-Ke, Tian Ye, Tabl Karim M., Mao Xiao-Ming, Li Pan, Feng Guang-Wu, Bai Xue-Chen, Liu Qian, Yan Wen-Hao, Liao Yu-Cai, Zhang Jing-Bo*, Yin Ping*, Wu Ai-Bo*. Specialized aldo-keto reductases trigger complete degradation of mycotoxin deoxynivalenol. Nature Communications 2026; doi: 10.1038/s41467-026-70007-z
  2. Yuan Qing-Song#, Yang Peng#, Liu Yi-Ke, Tabl Karim M., Guo Mao-Wei, Zhang Jing-Bo, Wu Ai-Bo, Liao Yu-Cai, Huang Tao*, He Wei-Jie*. Iturin and fengycin lipopeptides inhibit pathogenic Fusarium by targeting multiple components of the cell membrane and their regulative effects in wheat. Journal of Integrative Plant Biology 2025;67(8):2184-2197
  3. He Wei-Jie, Yang Peng, Huang Tao, Liu Yu-Fan, Zhang Yu-Wei, Zhang Wen-Min, Zhang Tian-Tian, Zheng Meng-Ru, Ma Ling, Zhao Chang-Xing, Li He-Ping, Liao Yu-Cai, Wu Ai-Bo, Zhang Jing-Bo*. Detoxifying bacterial genes for deoxynivalenol epimerization confer durable resistance to Fusarium head blight in wheat. Plant Biotechnology Journal 2024;22(9):2395-2409
  4. He Wei-Jie#, Zhang Tian-Tian#, Zheng Meng-Ru, Tabl Karim M., Huang Tao, Liao Yu-Cai, Wu Ai-Bo, Zhang Jing-Bo*. Utilization of a novel soil-isolated strain Devosia insulae FS10-7 for deoxynivalenol degradation and biocontrol of Fusarium crown rot in wheat. Phytopathology 2024;114(5):1057-1067
  5. He Wei-Jie, Shi Meng-Meng, Yang Peng, Huang Tao, Zhao Yue, Wu Ai-Bo, Dong Wu-Bei, Li He-Ping, Zhang Jing-Bo*, Liao Yu-Cai*. A quinone-dependent dehydrogenase and two NADPH dependent aldo/keto reductases detoxify deoxynivalenol in wheat via epimerization in a Devosia strain. Food Chemistry 2020;321(1):126703
  6. He Wei-Jie, Shi Meng-Meng, Yang Peng, Huang Tao, Yuan Qing-Song, Yi Shu-Yuan, Wu Ai-Bo, Li He-Ping, Gao Chun-Bao, Zhang Jing-Bo*, Liao Yu-Cai*. Novel soil bacterium strain Desulfitobacterium sp. PGC-3-9 detoxifies trichothecene mycotoxins in wheat via de-epoxidation under aerobic and anaerobic conditions. Toxins 2020;12(6):363
  7. He Wei-Jie, Zhang Limin, Yi Shu-Yuan, Tang Xue-Ling, Yuan Qing-Song, Guo Mao-Wei, Wu Ai-Bo, Qu Bo, Li He-Ping, Liao Yu-Cai*. An aldo-keto reductase is responsible for Fusarium toxin-degrading activity in a soil Sphingomonas strain. Scientific Reports 2017;7(1):9549
  8. He Wei-Jie, Yuan Qing-Song, Zhang You-Bing, Guo Mao-Wei, Gong An-Dong, Zhang Jing-Bo, Wu Ai-Bo, Huang Tao, Qu Bo, Li He-Ping*, Liao Yu-Cai*. Aerobic de-epoxydation of trichothecene mycotoxins by a soil bacterial consortium isolated using in situ soil enrichment. Toxins 2016;8(10):277
  9. 何伟杰, 刘易科, 朱展望, 张静柏, 高春保, 廖玉才*. 镰刀菌毒素脱氧雪腐镰刀菌烯醇脱毒菌及脱毒酶研究进展. 植物病理学报 2019;49(5):577-589